(2R)-1-Fmoc-2-azetidinecarboxylic acid

(2R)-1-Fmoc-2-azetidinecarboxylic acid - Names and Identifiers

Name	(R)-N-FMOC-Azetidine-2-carboxylic acid
Synonyms	D-Fmoc-Azetidine-2-carboxylic acid FMoc-(R)-azetidine-2-carboxylic acid (2R)-1-Fmoc-2-azetidinecarboxylic acid (2R)-1-FMoc-2-azetidinecarboxylic acid (R)-N-FMOC-Azetidine-2-carboxylic acid (R)-N-Fmoc-Azetidine-2-carboxylicacid(e.e.) (R)-N-(9-Fluorenylmethoxycarbonyl)-azetidine-2-carboxylic acid (2R)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]azetidine-2-carboxylate (R)-1-(((9H-fluoren-9-yl)Methoxy)carbonyl)azetidine-2-carboxylic acid 1,2-Azetidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester, (2R)-
CAS	374791-02-3
InChI	InChI=1/C19H17NO4/c21-18(22)17-9-10-20(17)19(23)24-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16-17H,9-11H2,(H,21,22)/p-1/t17-/m1/s1

(2R)-1-Fmoc-2-azetidinecarboxylic acid - Physico-chemical Properties

Molecular Formula	C19H17NO4
Molar Mass	323.34
Density	1.2675 (rough estimate)
Melting Point	139.4°C
Boling Point	461.82°C (rough estimate)
Flash Point	282.3°C
Vapor Presure	1.24E-12mmHg at 25°C
pKa	3.95±0.20(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.5000 (estimate)

(2R)-1-Fmoc-2-azetidinecarboxylic acid - Risk and Safety

Safety Description

S24/25 - Avoid contact with skin and eyes.

(2R)-1-Fmoc-2-azetidinecarboxylic acid - Introduction

(R)-N-FMOC-Azetidine-2-carboxylic acid, also known as (R)-N-FMOC-Azetidine-2-carboxylic acid, is an organic compound. Its molecular formula is C18H17NO4 and its relative molecular mass is 311.34. The following is a description of its nature, use, formulation and safety information:

Nature:
(R)-N-FMOC-Azetidine-2-carboxylic acid is a white to yellowish solid with a distinctive fragrance. It is stable at room temperature and can be dissolved in most organic solvents such as dichloromethane, dimethylformamide, etc.

Use:
(R)-N-FMOC-Azetidine-2-carboxylic acid is commonly used in organic synthesis as a chiral inducer. It can be used for the synthesis of chiral drugs, chiral catalysts for organic synthesis reactions, and chiral ion exchangers in solid phase synthesis. It can also be used for the synthesis of biologically active chiral compounds, etc.

Preparation Method:
(R)-N-FMOC-Azetidine-2-carboxylic acid can be prepared by a variety of methods. One of the commonly used methods is to react azetidine with 2-bromoacetic acid to obtain 2-azetidinecarboxylic acid, and then react 2-azetidinecarboxylic acid with Fmoc-Cl to obtain the target product.

Safety Information:
(R)-N-FMOC-Azetidine-2-carboxylic acid is generally safe under normal operation, but the following matters still need to be paid attention:
1. avoid contact with skin and eyes, such as accidental contact, should immediately rinse with plenty of water.
2. Good ventilation measures should be taken during operation, and it is recommended to equip the laboratory with an exhaust system.
3. storage should be sealed to avoid contact with air, moisture and other substances.

Last Update：2024-04-09 15:17:57